|These catalyzed reactions are widely used methods to efficiently increase molecular complexity in pharmaceutical, polymer, and natural product syntheses||Reaction mechanisms cannot be proven, but rather postulated based on empirical experimentation and deduction|
|In the simplest case, a synthesis reaction occurs when two molecules combine to form a third, more complex product molecule||Ensuring safe operating conditions, minimizing human exposure, and gaining the maximum amount of information from each experiment are key factors in successfully designing and scaling-up highly reactive chemistries|
These chemistries often involve highly exothermic reactions which require specialized equipment or extreme operating conditions such as low temperature to ensure adequate control.30
|Halogenation occurs when one of more fluorine, chlorine, bromine, or iodine atoms replace one or more hydrogen atoms in an organic compound||In situ FTIR spectroscopy provides information to support reaction mechanisms hypotheses|
|Often, synthesis reactions are more complex and require a thorough understanding of the kinetics and mechanisms of the underlying chemistry, as well as carefully controlled reaction conditions||These chemistries often involve highly exothermic reactions which require specialized equipment or extreme operating conditions such as low temperature to ensure adequate control|
Depending on the specific halogen, the nature of the substrate molecule and overall reaction conditions, halogenation reactions can be very energetic and follow different pathways.